Kratom contains more than 40 bioactive alkaloids; however, not all of them are as strong and potent as 7-hydroxymitragynine. While mitragynine is found in most quantities, 7-hydroxymitragynine is responsible for more effects, mainly pain relief and mood enhancement.
Apart from these two primary alkaloids, there are some minor alkaloids too, like Paynantheine, Speciogynine, Ajmalicine, Mitraphylline, and many more.
In this article, we will explore what 7-hydroxymitragynine is and how it works, its effects compared to other alkaloids, benefits and potential risks, safety guidelines, and where you can find high-quality 7-OH products.
What Is 7-Hydroxymitragynine (7-OH)?
7-hydroxymitragynine is found in minor quantities, but it is a highly potent alkaloid that makes up 0.01-0.03% of the total alkaloid content. The effect of 7-hydroxymitragynine is stronger than that of mitragynine due to its high affinity for opioid receptors.
Key Facts About 7-OH:
- The molecular formula of 7-OH is C23H30N2O5.
- 7-OH primarily binds to μ-opioid receptors, which is similar to morphine but in a different way.
- The bioavailability of 7-hydroxymitragynine is higher than mitragynine, especially if consumed orally.
- The half-life of 7-OH is longer than mitragynine, approximately 3 to 4 hours.
How Does 7-OH Work in the Body?
7-hydroxymitragynine is more effective in pain relief as it is a full agonist at μ-opioid receptors, unlike mitragynine, which is a partial opioid agonist.
Pharmacological Effects:
It provides four types of pharmacological effects: pain relief, mood enhancement, sedation and relaxation, and anti-inflammatory action. 7-hydroxymitragynine has strong analgesic properties due to its high receptor binding. It activates dopamine and serotonin pathways that help in mood improvement. Higher dosage of 7-OH produces calming effects, causing sedition and relaxation. All inflammation-related pain also reduces in 7-OH consumption.
Comparison to Mitragynine & Morphine
Here is a quick comparison table of mitragynine, morphine, and 7-Hydroxymitragynine.
| Feature | 7-Hydroxymitragynine | Mitragynine | Morphine |
| Potency | 10–30x mitragynine | Baseline | Stronger |
| Receptor Binding | Full μ-opioid agonist | Partial agonist | Full agonist |
| Pain Relief | Very strong | Moderate | Very strong |
| Addiction Risk | Lower than morphine | Low | High |
| Respiratory Depression | Minimal risk | None | High risk |
Benefits of 7-Hydroxymitragynine
- It provides superior pain relief; such as chronic pain, arthritis, and neuropathy. It does not suppress breathing like traditional opioids.
- 7-hydroxymitragynine provides long-lasting effects compared to mitragynine. It generally lasts up to 7 hours.
- It provides relaxation and improvement in mood without euphoria and intense highs.
- 7-OH has a lower risk of dependency than other traditional opioids like morphine or oxycodone, and it also does not cause severe withdrawal symptoms.
Potential Risks & Side Effects
7-OH does not pose bigger risks as it is generally well-tolerated; however, improper use can lead to:
Tolerance buildup
Frequent use of 7-OH reduces its effectiveness and leads to tolerance buildup over time. To avoid this, you can rotate strains and take short breaks.
Mild Side effects
Mild side effects such as nausea, dizziness, and constipation are reported; however, you can avoid them by staying hydrated, consuming in smaller amounts, and avoiding taking on an empty stomach.
Overuse Risks
Overuse risk persists in all types of alkaloids. You can avoid them by consuming a safe dose (1-5mg) in one serving. A high dose of 7-hydroxymitragynine is 10 mg+, which can cause sedation.
How to Use 7-OH Safely?
Choosing the Right Product
7-OH is available in various forms such as extracts, tinctures, tablets, powder, and capsules.
Both tablets and extracts have a good concentration of 7-hydroxymitragynine and ensure precise dosing. They are also available in various flavours. 7-OH tablets are easy to consume and affordable as well. You can buy high-quality 7-OH tablets here; available in Sour Apple flavor.
Along with high-concentration 7-hydroxymitragynine tablets, Occurs Naturally also offers Pseudo Red and a blend of 7-hydroxy + Pseudo kratom tablets in strawberry and blue raspberry flavors. You can enjoy three targeted effects: relief, energy, and focus.
Proper Dosage Guidelines
Below are some guidelines for kratom consumption. Avoid taking 10mg + in a single dose.
| Experience Level | Dosage (7-OH Extract) | Effects |
| Beginner | 1–2 mg | Mild pain relief, relaxation |
| Intermediate | 2–4 mg | Strong pain relief, mood boost |
| Advanced | 4–6 mg | Deep relaxation, sedation |
Best Consumption Methods
- Sublingual 7-OH Tinctures provide the fastest absorption in the bloodstream and give instant effects.
- Encapsulated 7-OH Extracts provide longer-lasting effects.
- 7-OH tablets provide balanced and more targeted effects.
Conclusion
When purchasing 7-hydroxymitragynine products, always verify the seller by checking third-party lab testing reports, transparent labelling, and positive customer reviews. Extremely cheap products, exaggerated medical claims, along with no lab reports, are signs of scams and unreliable vendors.
7-OH is the most potent alkaloid that offers intense pain relief, relaxation, and mood improvement with a lower risk profile than traditional opioids. 7-hydroxymitragynine is highly effective but should be consumed with caution.
Read our blog for more details related to 7-hydroxymitragynine and other alkaloids present in kratom.
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