There are two main alkaloids found in kratom: mitragynine and 7-hydroxymitragynine. While mitragynine is found in most quantities, the effects, like sedation, are due to 7-hydroxymitragynine, which is more potent as compared to other alkaloids present.
7-OH is responsible for many notable effects, mainly pain-relieving properties. In this guide, we will explore what 7-OH is, its benefits, and how it compares to other substances such as morphine.
What is 7-Hydroxymitragynine (7-OH)?
7-hydroxymitragynine is an active terpenoid indole alkaloid found in Mitragyna speciosa, a botanical plant native to Southeast Asian countries like Thailand, Indonesia, and Malaysia. Discovered in 1994, it is a derivative of mitragynine, another compound present in kratom leaves.
7-OH is a naturally occurring alkaloid in kratom. It is present in smaller quantities than mitragynine. However, it is far more potent and strong due to binding with the body’s opioid receptors, mainly the mu-opioid receptors, which are linked with pain relief and euphoria.
Molecular formula: C23H30N2O5
Molecular weight: 414.50 g/mol
Key Facts About 7-OH:
7-OH is 10 to 30x stronger than mitragynine. It provides effects like strong pain relief, mood enhancement, and relaxation. Some online vendors extract 7-OH and provide specially formulated kratom products that provide stronger effects, such as focus tablets by On7, which provide a concentrated amount of 7-OH that enhances energy and vitality.
These tablets are perfect for busy days or whenever you need an extra push. It allows you to enjoy sustained energy without the crash.
Uses of 7-OH
Due to the stronger potency, 7-OH is mainly used for:
1. Pain Relief
7-OH provides pain relief by binding with opioid receptors similarly to pharmaceutical pain killers, but without any side effects. It is highly effective to deal with chronic pain, arthritis, and muscle soreness.
2. Relaxation & Stress Relief
7-OH also promotes relaxation and stress relief without excessive sedation. It also helps in easing tension and anxiety.
3. Enhanced Mood
7-OH is beneficial for people dealing with fatigue or low mood levels. It generally induces mild euphoria and emotional well-being.
4. Sleep Support
7-OH also aids in sleep disturbance, mainly insomnia.
Benefits of 7-OH
7-OH is stronger and more effective in treating chronic pain due to its high receptor affinity. It provides long-lasting effects up to 7 hours, as compared to mitragynine, which is 3 to 4 hours.
While strong and potent, it causes fewer digestive issues like nausea if compared with traditional opioids. 7-OH also helps individuals switch to natural alternatives to pharmaceutical and synthetic opioids.
7-hydroxymitragynine is available in many forms; however, tablets are the most convenient option. At On7, we provide premium-grade 7-OH products with concentrated dosage, crafted with care and precision to ensure the best results.
7-OH Compared to Morphine
| Feature | 7-Hydroxymitragynine (7-OH) | Morphine |
| Source | Natural (kratom plant) | Synthetic/Semi-Synthetic |
| Potency | ~13x stronger than mitragynine | Stronger overall but varies by dose |
| Pain Relief | Highly effective, longer-lasting | Fast-acting but shorter duration |
| Addiction Risk | Lower dependence potential | High risk of dependence |
| Side Effects | Milder (nausea, dizziness) | Severe (respiratory depression, constipation) |
| Legal Status | Unregulated in most areas | Controlled substance |
Why 7-OH is Gaining Attention:
- It is safer than morphine with similar pain-relieving properties.
- It possesses less risk of respiratory diseases, which is a major issue with traditional opioids.
- It has a natural plant-based background, which makes it appealing to people looking for natural alternatives to pharmaceutical medicines.
How to Use 7-OH Safely?
- Choose rich 7-OH extracts such as powders and shots. Try high-quality red vein kratom, which has a naturally high concentration of 7-OH.
- Start with a low dose, mainly half of your regular dose, and gradually increase as needed. 7-OH is high in potency, so caution is a must while consuming.
- Avoid frequent consumption. To prevent tolerance, only use 2-3 times per week.
- While consuming 7-OH, drink plenty of water to minimise side effects like dizziness and dry mouth.
Potential Side Effects
While it is generally well tolerated, some users have reported side effects like drowsiness, nausea, constipation, and dependence. However, these symptoms are less than morphine.
To avoid potential side effects, it is advisable to drink plenty of water, avoid higher doses in prolonged use, and opt for high-quality kratom.
Conclusion
7-OH is a strong and potent alkaloid that offers pain relief and relaxation. Most people use it for dealing with chronic pain, stress relief, and mood improvement with fewer risks than morphine.
If you are considering 7-OH products, always buy from reputable vendors who disclose their lab test results and analysis certificates to ensure transparency. 7-OH products are stronger, which increases the caution to start with a minimum dose of 1-2 grams.
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